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Phentermine vs Reductil Differences

Phentermine and Reductil are medications that are effective for treatment of obese people. These medications were designed for people with BMI over 30 or people with BMI over 27 but with high amount of fat in the blood, type 2 diabetes and hypertension.

Pharmacological properties
reductil sibutramine vs phentermine Phentermine and Reductil belong to the group of weight loss drugs, called anorectics or appetite suppressants. Anorectics affect the central nervous system (CNS), thus depressing appetite. Loss of appetite, caused by Phentermine or Reductil, ultimately promotes weight loss. At that, Reductil and Phentermine affect different parts of the CNS.
Reductil anorexigenic effect is provided by metabolites that are secondary and primary amines.
Thus, Reductil:
- Inhibits monoamines reuptake (serotonin and norepinephrine)
- Reduces appetite by altering central noradrenergic functions
- Increases thermogenesis by activating beta3-adrenoceptors
- Reduces the quantity of brown adipose tissue in the body
Appetite suppressant effect of Phentermine is reached by its action on the hypothalamus, as well as dopaminergic and noradrenergic nervous system areas. Phentermine slimming pills:
- Suppress appetite and increase the feeling of satiety
- Increase energy and physical endurance
- Prevent re-accumulation of fat mass

Contraindication for Phentermine and Sibutramine use
Contraindications for Reductil use to treat exogenous obesity almost coincide with contraindications for Phentermine use to suppress the appetite.
Use of Phentermine and Reductil medications are contraindicated in: cardiovascular diseases; glaucoma; pulmonary hypertension; arterial hypertension; hyperthyroidism; simultaneous use with other drugs for weight loss; serotonin reuptake inhibitors (Paroxetine, Fluoxetine, Fluvoxamine, Sertraline); MAOIs use (Iproniazid; Moclobemide; Metralindole; Selegiline).
In contrast to Reductil drug which is contraindicated in anorexia nervosa, bulimia, severe liver or kidney dysfunction, Phentermine drug may be prescribed to treat obesity in patients with eating disorders and patients with liver or kidney failure.

Side effects
At the beginning of anti-obesity therapy with anorectics Reductil and Phentermine, the following side effects are possible: dizziness, nausea, dry mouth, restlessness, sleeplessness, diarrhea or constipation, palpitations.
Side effects are usually mild and disappear on their own within a few days from the start of Phentermine or Reductil use. In rare cases, Phentermine pills may be discontinued because of tachycardia and (or) arrhythmia.
In certain cases of Reductil treatment, unusual side effects were observed, such as acute interstitial nephritis, seizures, transient increase in liver enzymes, and thrombocytopenia.

In addition, Phentermine and Reductil diet pills cannot be used in pregnancy and during breastfeeding. Using these drugs increases the risk of mental and physical abnormalities during the development of a child.
In most countries of the world, Phentermine and Reductil are not prescribed to patients, aged under 18 or over 65 years. Using any of these diet pills, patients should keep out of MAO inhibitors and drugs that can affect serotonin level.
If during the use of Phentermine or Reductil a patient doesn't have any significant weight loss, then the doctor can recommend to change the dosage or to refuse from these diet pills.